Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0313043
PubChem CID
Molecular Formula
C12H12N4
Molecular Weight
212.256 g/mol
Synonyms/Alias
[CHEMBL64276; 2-Pyrrolidin-1-yl-1H-pyrrolo[3;2-b]pyridine-3-carbonitrile; SCHEMBL6683225; YHKFYZRAKLMSLI-UHFFFAOYSA-N; BDBM50128980; 2-Pyrrolidin-1-yl-1H-pyrrolo [3;2-b]pyridine-3 -carbonitrile]
InChI Key
YHKFYZRAKLMSLI-UHFFFAOYSA-N
InChI
InChI=1S/C12H12N4/c13-8-9-11-10(4-3-5-14-11)15-12(9)16-6-1-2-7-16/h3-5,15H,1-2,6-7H2
IUPAC Name
2-pyrrolidin-1-yl-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

16 18 0 0 0 0 0 0 0 0999 V2000
-4.4361 0.1695 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.3815 -1.3295 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.9390 -1...

Experimental Data

Activity Data

Target Ion Channel
Calcium activated potassium channel subunit alpha-1
Uniprot Accession Number
Function
Opener
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 8119 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
Not specified
Temperature
37 °C
Test Method
Efflux Assay ([86] Rubidium Ion)
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
16
Rotatable Bonds
1
logP
2.0348
Complexity
62.2557
TPSA (Ų)
55.71
H-Bond Donors
1
H-Bond Acceptors
3
Ring Count
3
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